John Estrete, the eminent judge and statesman, owned a house here in 1483, which he sold to Philip Fleming two years later.

Fishamble Street was the birthplace of both Henry Grattan, an Irish politician and lawyer, and James Clarence Mangan, a 19th-century poet.

[4] The General Post Office was located here and remained for around 30 years before moving to Sycamore Alley and later again to Fownes Court in Temple Bar and then to College Green.

The Church of St. John the Evangelist was located here until it was demolished around 1884 as part of larger works which included the laying out of Lord Edward Street.

In the 18th century, a tavern on the street, the Bull's Head, was one of the most popular and well-known establishments in Dublin, and was in demand for anniversary and celebratory dinners by the various city guilds and bodies.