[2][3] Five & Alive was established by Kate Roberts in 2007 as a subsidiary program of Population Services International, where she serves as Vice President of Corporate Marketing and Communications.

[5] Five & Alive has promoted oral rehydration salts (ORS) and zinc supplements for children who may die from diarrhea-related dehydration.

[5] Five & Alive's pre-packaged therapy kits that contain cotrimoxazole were provided through private sector clinics to treat pneumonia in children under five.

[8] Five & Alive promotes a set of interventions that includes breastfeeding, kangaroo mother care, and delayed bathing.

They also provide an opportunity for travelers to donate financially and purchase merchandise in their onboard retail shops.