Barbara Pierce Bush was born on November 25, 1981 at Baylor University Medical Center in Dallas, Texas.

[9][10][11][12] Her interest in the issue began when she went to Africa with her parents to launch President Bush's Emergency Plan For AIDS Relief (PEPFAR).

[16][17] Bush was also chosen as one of the 14 speakers selected from an applicant pool of 1,500 to speak at the TEDx Brooklyn event in December 2010, where she spoke about Global Health Corps.

She and Jenna made several media appearances that summer prior to the 2004 U.S. presidential election, including giving a speech to the Republican Convention on August 31.

[21] She and Jenna took turns traveling to swing states with their father and also gave a seven-page interview and photo shoot in Vogue.

[22][23] Jenna later confirmed that she and Barbara both had developed a friendship with John Kerry's daughters, Alexandra and Vanessa, who had similarly campaigned on behalf of their own father (who was the Democratic nominee for president).

[24] Bush joined her mother on diplomatic trips to Liberia in January 2006 to attend the inauguration of President Ellen Johnson Sirleaf[25] and to Vatican City to meet with Pope Benedict XVI in February 2006.