[13] Moore became interested in singing and acting at a young age, and called her British maternal grandmother, Eileen Friedman, a professional ballerina in London, one of her inspirations.

[2] Production director Konnie Kittrell said about Moore "She was a quiet, sweet girl", and said that she earned a number of solos, but "She wasn't a spotlight seeker.

[47] "Walk Me Home" was re-released in the United States as the second single from I Wanna Be with You and was slightly more successful than its original release, peaking at number 38 on the Billboard Pop Songs chart.

[61] Moore made her feature film debut in 2001, where she voiced a Girl Bear Cub in the comedy Dr. Dolittle 2, which starred Eddie Murphy.

Later that year, Moore's cover of Carole King's 1971 song "I Feel the Earth Move" was included on the compilation album Love Rocks from LGBT rights supporters.

In 2003, Moore co-starred with Allison Janney, Peter Gallagher, and Trent Ford in the romantic comedy-drama How to Deal which was based on Sarah Dessen's novels That Summer and Someone like You.

She played Halley Martin, a cynical and rebellious seventeen-year-old who deals with falling in love with Macon Forrester (Ford), the new boy at her school and her relationships and issues with her family and friends.

"[84] Late in 2004, Moore co-starred with Jena Malone, Macaulay Culkin and Patrick Fugit in the religion satirical comedy-drama Saved!.

The same year, she guest-starred in the Fox animated sitcom The Simpsons, where she voiced Tabitha Vixx in the seventeenth-season finale called "Marge and Homer Turn a Couple Play".

[90] Moore co-starred with Hugh Grant, Dennis Quaid and William Dafoe in Paul Weitz's satirical comedy American Dreamz, which was released in April 2006.

"[97] Later in 2006, Moore voiced Nita, the heroine of the Disney animated sequel Brother Bear 2, which was released directly to DVD on August 29, 2006.

The film was released on February 2, 2007, and received mixed to negative reviews, but was a financial success, earning over $69 million worldwide at the box office.

[104] Later that year, Moore co-starred with John Krasinski and Robin Williams in the romantic comedy License to Wed which was released on July 3, 2007.

Gone is the sugary pop of Moore's early career, replaced instead by thoughtful musings on love and life…an album full of subtle, but undeniable hooks.

[123][122] The album's lead single "I Could Break Your Heart Any Day of the Week" was released on March 17, 2009, and its music video premiered on April 20, 2009, on Yahoo!

[138] In 2010, Moore made a guest-starring appearance as Mary Portman in the ABC medical drama Grey's Anatomy, for the two-part sixth-season finale, her first television role since 2007.

[140] Also that year, Moore co-starred with Zachary Levi where she voiced Rapunzel in the CGI Disney animated fantasy musical comedy Tangled.

[141] The site's consensus read: "While far from Disney's greatest film, Tangled is a visually stunning, thoroughly entertaining addition to the studio's classic animated canon.

[152] In 2012, she co-starred with Carla Gugino and Rufus Sewell in Sebastian Gutierrez's crime drama Hotel Noir, which was released on October 9, 2012, in the U.S.[citation needed] From 2012 to 2013, Moore voiced Mara in the short-lived Disney XD animated science fiction series Tron: Uprising.

[162] In June 2015, it was confirmed that Moore and Levi would reprise their roles as Rapunzel and Eugene "Flynn Rider" Fitzherbert in an animated television series based on Tangled.

"[168] In September 2016, Moore began co-starring as Rebecca Pearson in the NBC family comedy-drama This Is Us, where she later received a Golden Globe Award nomination for her role.

[173][174] In November, she reprised her role as Rapunzel in the Disney CGI animated comedy Ralph Breaks the Internet with John C. Reilly, Sarah Silverman, Gal Gadot, Taraji P. Henson, Kristen Bell and Jane Lynch.

[175][176] The film grossed almost $500 million worldwide and received generally positive reviews from critics, who called it a "worthy successor" and praised the animation, humor, characters, plot and the vocal performances of Reilly and Silverman.

[179][180] In February 2019, Moore co-starred with Justin Bartha, Barbara Jacques and Paul Lieberstein in the short comedic action film The Big Break.

[181] In March, she co-starred with J.K. Simmons, Sebastian Stan, Max Greenfield and Maika Monroe in the drama I'm Not Here[citation needed] and voiced Courtney in the Fox animated sitcom Family Guy, in the season 17 episode "No Giggity, No Doubt".

[185] In November, she co-starred in the independent historical drama Midway with Ed Skrein, Patrick Wilson, Luke Evans, Aaron Eckhart, Nick Jonas, Dennis Quaid, and Woody Harrelson.

It was accompanied by a cameo-laden music video which featured many of her This Is Us co-stars in addition to Wilmer Valderrama, Hilary Duff, Matthew Koma, Amanda Kloots, and Karamo Brown, among others.

[199] AllMusic said, "Moore smoothly evolved from adolescent starlet to mature songwriter, continuing to distance herself from the scene that had launched her career one decade prior".

[204] Moore has worked with and highlighted nonprofit organization Population Services International (PSI), and its subsidiary, Five & Alive, which addresses health crises facing children under the age of five and their families.

[246] In August 2022, Moore was diagnosed with immune thrombocytopenic purpura, an incurable but treatable autoimmune disease that causes abnormally low levels of platelets.