[2] Orsina married Marcantonio Colonna, Duke of Tagliacozzo; Alessandro became Cardinal and Michele became Prince of Venafro.

However, Ferdinando de' Medici, brother of Francesco I of Tuscany, given her in marriage to Virginio Orsini, Duke of Bracciano.

In addition to performing herself, she hosted virtuosos such as Luca Marenzio, Vittoria Archilei and Francesco Rasi.

She took part in all the social events of the period, including the marriage of Maria de' Medici to the French King Henry IV.

[3][8] Flavia died at thirty-two during her twelfth delivery, on 14 September 1606, giving birth to a stillborn daughter.