Titiana married Publius Helvius Pertinax, a wealthy self-made man who had a successful military and civil career.

She bore two children, a boy named Publius Helvius Pertinax and a daughter.

While the new princeps was offering the customary sacrifice on the Capitoline Hill, the Roman Senate gave Flavia Titiana the honorary title of Augusta.

[citation needed] After the murder of Pertinax by the Praetorian Guard on March 28, neither Flavia nor her children were hurt.

The highly unreliable Historia Augusta claims that Flavia Titiana "carried on an amour quite openly with a man who sang to the lyre", but Pertinax was not concerned.