[3] Florence first became interested in politics after listening to her father's discussions with fellow politicians, such as Richard J. Oglesby, David Davis and Jesse W.

Seeing the need for a local sanitarium, she formed the McLean County Tuberculosis Association with four other community members.

Florence began traveling across McLean County, educating citizens on the symptoms of tuberculosis and checking children's health with the help of a nurse.

Additionally, in response to concerns about children's health, the county initiated a hot lunch program in rural schools.

Her platform included progressive welfare work, balancing power between Chicago and downstate, and lessening taxation.

[12] In the fall elections, Florence's campaign focused on increasing law enforcement, the protection of agricultural interests, and the reduction of taxes.

[14] Florence served on numerous committees in the senate, including ones related to charity, civil service, the economy, and public safety.

[16] Florence also introduced the Midwife Bill, which would have provided training and state licensing for midwives.

The recent death of her husband and mother hindered her ability to campaign, and support for the Republican Party was waning.