Florence Oboshie Sai-Cofie (née Sai; born 6 April 1953), is a Ghanaian politician and a media executive.

On 1 August 2007, she served as Minister of Information and National Orientation under president kufuor's administration succeeding Kwamina Bartels.

[2][3] She subsequently served as Minister of Tourism and Diaspora relations,[4] also Sai Cofie held the position of board chair of the Ghana Airports Company.

[citation needed] In 1979, Sai Cofie moved to the United States and began working at Afam Concept Chicago as a regional sales and marketing director.

In 1989, Sai Cofie returned to Ghana and engaged in several enterprises including a popular confectionery called Osibix Confections.