It travels from SR 21 in Lake Shore, heading north, then east to end at US 17 in Oceanway.

The road changes names again to Edgewood Avenue North after crossing US 90 (West Beaver Street).

Continuing north, SR 111, still a mix of residential and commercial businesses, crosses Commonwealth Avenue, followed by a CSX rail line.

East of this interchange, SR 111 changes names to Edgewood Avenue West and the divided highway ends as the road continues northeast through residential areas on Jacksonville's north side.

East of the interchange, it changes names to Tallulah Avenue and heads southeast, towards a crossing of the St. Johns River, through residential areas as it meets its northern terminus at US 17 (North Main Street).