It passes through the towns of Starke and Green Cove Springs in addition to providing access to Camp Blanding.

From there it runs between the Florida State Prison and New River Correctional Institute, and remains at this general trajectory until it reaches Starke.

Leaving the city, the road bends slightly to the northeast and later crosses the Bradford-Clay County Line where it then encounters a sharp left curve to the north at a wye intersection with the eastern terminus of SR 230, only to curve back straight east again, where it has another intersection with the southern terminus of CR 225.

The southwestern terminus of CR 215 provides a shortcut towards Jacksonville, but the main road leading to that city is found later as SR 21, north of Belmore.

In Green Cove Springs, the road crosses the CSX Sanford Subdivision and the Clay County Historical Museum, then makes a sharp turn to the south at US 17, sharing an overlap with that route until the Leonard C Taylor Parkway, where it leaves US 17 and returns to the east.

It is a suffixed spur of SR 16 located just west of the city of Green Cove Springs serving residences around the northwest quadrant of Kingsley Lake.