Meigs Bridge over Rocky Bayou, exiting the Niceville city limits and entering Bluewater Bay.

3 miles later, the road intersects SR 293, providing access to Destin via the Mid-Bay Bridge before reducing to two lanes and entering Walton County.

Briefly after crossing the county line, SR 20 continues southeast before turning east into Choctaw Beach, skirting along the Choctawhatchee Bay, as a two lane road.

After Blountstown, the road becomes four lane, crossing the Apalachicola River on the Trammell Bridge into Liberty County.

After intersecting Stadium Drive, the roads head southeast again, passing along the north side of Florida State University.

Routes 20/27 head east along Apalachee Parkway out of Tallahassee, intersecting US 319/Capital Circle SE along the way.

US 19/SR 20/US 27 head into Taylor County as Byron Butler Parkway, retaining four lanes and southeasterly direction.

Curving slightly northeast, the routes intersect SR 349 and quickly enter Branford in Suwannee County.

The portion of SR 20 running through all of Calhoun County was designated as "Fuller Warren Parkway" by the Florida State Legislature in 1999.

[2] The portion of SR 20 that runs in a hidden concurrency with US 27 in Leon County was designated as "Apalachee Parkway" by the Florida State Legislature in 1961.

[3] The portion of SR 20 that runs in a hidden concurrency with US 27 in Leon, Jefferson, Madison, and Taylor counties was designated as "Blue Star Memorial Highway" by the Florida State Legislature in 1957.

[4] The same portion of SR 20 in Taylor, Jefferson, and Leon counties was also designated as "Paradise Drive" by the Florida State Legislature in 1951.

[6] The portion of SR 20 in Alachua County that runs in a hidden concurrency with US 441 was designated as "Martin Luther King Jr. Highway" by the Florida State Legislature in 1988.

[7] The portion of SR 20 in Alachua County that runs in a hidden concurrency with US 27 was designated as "United Spanish War Veterans Memorial Highway" by the Florida State Legislature in 1947.

[8] The entire portion of SR 20 that runs in a hidden concurrency with US 27 was designated as "Claude Pepper Memorial Highway" by the Florida State Legislature in 1999.

It begins at the southern terminus of State Road 21 in McMeekin, and runs southeast towards Johnson, and Edgar, finally reaching Interlachen, where it turns north to meet SR 20 again.

US 17-SR 100-Truck Route 20 all run over the abandoned grade crossing for the right-of-way of the former Atlantic Coast Line Railroad Rochelle Branch, then curves back to the east.