State Road 222 (SR 222) is a 14.174-mile-long state road that serves northern Gainesville.

The western terminus is at a diamond interchange with I-75 at exit 390, and the eastern terminus is at a fork at SR 26 just east of Gainesville.

It is 4 lanes wide, but narrows to 2 lanes east of Airport Access Road, where it runs along the northwestern edges of the Newnans Lake State Forest[2][3] followed by the Newnans Lake Conservation Area.

[4] At its western terminus, NW 39th Avenue continues west as two lane County Road 222 towards CR 241, a long county road.

The entire route is in Alachua County.