State Road 405 (SR 405) is a state highway making a sweeping arc in Titusville, Florida, and, via the nearby NASA Parkway, providing a major access route for the Kennedy Space Center on nearby Merritt Island.

The northern terminus of SR 405 is an intersection with North Washington Avenue (U.S. 1) in downtown Titusville; the eastern terminus is at a cloverleaf interchange with U.S. 1 near the American Police Hall of Fame & Museum.

It is locally known as South Street and Columbia Boulevard.

It parallels Interstate 95 for 2.2 miles (3.5 km) - from Cheney Highway to Willis Drive - before veering off to the northeast towards downtown Titusville.

In addition, SR 405 passes by Space Coast Regional Airport (formerly Ti-Co (Titusville-Cocoa) Airport) and Enchanted Forest Park.