With an interchange at Interstate 4 (I-4), SR 472 serves as the primary access to Orlando and Sanford from DeLand.

It also provides a direct route to Deltona, terminating at CR 4145 (Howland Boulevard/Graves Avenue).

SR 472 begins at an interchange with US 17/US 92 in between Orange City and DeLand in Volusia County, heading east as a four-lane divided highway.

The road passes through forested areas with some nearby development, curving to the southeast, skirting a corner of DeLand to the northeast The highway crosses CR 4101, at which point at again runs along the southern border of DeLand.

A short distance past this interchange, SR 472 reaches its eastern terminus at an intersection with CR 4145.