State Road 501 (SR 501) is a three-mile (5 km) long north–south highway entirely within Cocoa, Florida, in the United States.

It southern terminus is an intersection with King Street (SR 520); its northern terminus is an intersection with SR 524 just south of an interchange with State Road 528 and Grissom Parkway.

[citation needed] SR 501 is a commercial artery of Cocoa, with shopping centers on both sides of the street.

A campus of Brevard Community College is also located on Clearlake Road.

The entire route is in Brevard County.