It runs west from SR 71 almost without any acknowledgement, then shortly turns northwest before the intersection with County Road 73A.

In Kinard itself, the road takes a sharp turn more toward the north, and crosses a bridge over Cypress Creek before approaching a blinker-light intersection with CR 392.

SR 73 begins to run much closer to the Chipola River as it approaches the Calhoun-Jackson County Line.

From this point it acquires the name Clarksville Highway and after passing the Lighthouse Community Churchmore turns straight north again at the intersection of Tupelo Court.

Within the city, SR 73 makes a slight reverse curve to the right and then the left before it serves as what would appear to be the eastern terminus of CR 167 (South Street), and then crosses the CSX P&A Subdivision.

At the equivalent of two blocks later, SR 73 becomes a two-lane divided highway just south of the intersection with Jackson Street where it enters the Marianna Historic District.

US 90/SR/73/CR 164 serves as the southern border of the Marianna Historic District until the road intersects Wynn Street.

The US 90/SR 73 concurrency ends at the southeast leg of a wye intersection with US 90 which turns to the southwest beneath a bridge under the CSX P&A Subdivision.

It begins at the northern terminus of northern CR 73A as a continuation from Northwest White Pond Circle and runs east and west with one slight curve after Duck Pond then runs in a straight line only to turn to the southeast as it terminates at SR 73.