CR 758 begins at an intersection with the western terminus of SR 72 in Siesta Key, heading northwest on Midnight Pass Road, a two-lane divided highway.

The median becomes a center left-turn lane as the road heads through resort residential and commercial areas a short distance to the east of the Gulf of Mexico.

SR 758 intersects CR 789A again and turns north onto Higel Avenue, passing more homes in the northern part of Siesta Key.

The road passes through a mix of homes and businesses, intersecting South Shade Avenue before crossing Phillippi Creek.

Then it crosses Honore Avenue, and just before it intersects with Cattlemen Road it becomes a six-laned divided highway as it continues through areas of residential neighborhoods and businesses.

The county will be responsible for ongoing maintenance of those roadways, although the state would still maintain the bridges to Siesta Key.