State Road 76 (SR 76), also known and signed as Kanner Highway, is a 31.504-mile-long (50.701 km) northeast-southwest (signed east–west) state highway connecting Port Mayaca on the shore of Lake Okeechobee at the intersection with US 98-441 (SR 700-SR 15) with Stuart on the shore of the St. Lucie River near the Atlantic Ocean and the Treasure Coast at an intersection with US 1 (SR 5).

It parallels the nearby St. Lucie Canal, a navigable waterway connecting the lake and the ocean.

Northeast of the two expressways, the human presence is more pronounced (a marina is located on the canal between the turnpike and I-95, for example) as the urbanization undergone by Florida's extreme southeastern counties has penetrated Martin County.

After FDOT removed its State Road signs from the alternate route, new County Road 76A signs lined the rural streets in their place.

Recently, the urbanization that is now occurring on the northeastern end of SR 76 is also occurring along the eastern half of CR 722 as construction of new residential developments continues.