Port Salerno is an unincorporated community and census-designated place (CDP) in Martin County, Florida, United States.

Early settlers were fisherman who lived along the banks of the Manatee Pocket, a small natural bay in the St. Lucie River.

Some descendants of these original settlers remain in the area, with some families owning land for over 100 years.

The area increased in population and importance after World War II, with many people from the northeastern United States moving to Florida.

This grocery store was featured in the production[6] in Palm Beach Gardens,[7] but had been transformed into a saloon before being filmed.

Sally Field mentioned the town and resort in an interview with Johnny Carson on The Tonight Show.

[citation needed] In the 1980s, the Chastain Campus of Indian River State College was established.

Martin County Public Transit (MARTY) provides fixed-route bus service through Port Salerno.