Flossie Wong-Staal (née Wong Yee Ching, Chinese: 黄以静; pinyin: Huáng Yǐjìng; August 27, 1946 – July 8, 2020) was a Chinese-American virologist and molecular biologist.

From 1990 to 2002, she held the Florence Riford Chair in AIDS Research at the University of California, San Diego (UCSD).

[4][2] When she was 18, she left Hong Kong to attend the University of California, Los Angeles, where she pursued a Bachelor of Science degree in bacteriology.

[5] In 1990, Wong-Staal was recruited from NCI to the University of California, San Diego (UCSD), where she started the Center for AIDS Research.

Wong-Staal's research focused on gene therapy, using a ribozyme "molecular knife" to repress HIV in stem cells.

[10] Wong-Staal used a type of cellular analysis known as radioimmunoprecipitation in order to detect the presence of KS lesions in cells with varying amounts of the Tat protein.

[8] In that same year, Wong-Staal was elected to the Institute of Medicine of the U.S. National Academies,[12][13] and to Taiwan's Academia Sinica.

[14] In 1995, Wong-Staal was elected to the board of directors of United Biomedical, Inc. (UBI), where she had previously served as a consultant and scientific advisor.

She then joined Immusol, a biopharmaceutical company that she co-founded with her second husband, Jeffrey McKelvy,[16] while she was at UCSD, as chief scientific officer.

[22][23] Wong-Staal died on July 8, 2020, at the age of 73, at Jacobs Medical Center in La Jolla, due to complications caused by pneumonia.