The club was first founded in 1932 (unofficially existed from 1928) under the name "Panamfissaikos" and twenty years later (1952) was renamed to "Amfissaikos".

During the Delphic Festival of 1926 Athletes of Desfina conquered most medals, so their colleagues from Amfissa who participated in national competitions, to be resented and urged a revived interest in the sport, which had died down.

The poet was particularly concerned about the area, organizing the Delphic Festival and showed unfailing interest in the newly established club.

During the 1960s and 1970s Fokida and Fthiotida champions had participated in a "special amateur's championship" which promoted 1 team for the 2nd National League.

Three years later, Fokikos returned to the National Amateur's Championship (1985), beating Pallamiakos (1–0), in extra game.

As the National Amateur's Championship becomes the fourth division of Greek football, Fokikos returned in 1990, finally losing the title to A.P.S.

Players involved: Anagnostopoulos, Karampelousis, Aravanis, Katsimpardis, Papadimas, Karadimos, Manetas, Livas, Stephanopoulos, Markodimos, A.

On the occasion of 80 years since the formal establishment of the team in 1932, both Club Management and Fokikos' fans prepare a series of events as well as projects including a book publication by Tsigas Elias and Avramikos Nickolaos, as responsible authors.