Fond du Lac High School has an enrollment of approximately 2000 students.

[3] Advanced placement (AP) classes offered at Fond du Lac High School include calculus, chemistry, physics, psychology, U.S. politics and government, biology, U.S History, statistics, computer science, music theory, language and composition, and literature and composition.

A few CAPP (Cooperative Academic Partnership Programs) and other concurrent enrollment options are offered by the University of Wisconsin–Oshkosh.

24 sports are currently offered:[5] The football team is notable for having ended two of the longest winning streaks in Wisconsin high school history.

On October 31, 1987, the Cardinals ended the then-record 48-game winning streak of Manitowoc Lincoln Ships with a 27-15 victory at Fruth Field in Fond du Lac in the sectional final (quarterfinals) of the WIAA playoffs.