As of fall 2008, approximately 2250 students were enrolled in grades 9 through 12, making it one of the largest schools in the state.

[3] A successful 2020 referendum budgeted $115 million for a new high school to be built in the town of Neenah, although the village of Fox Crossing later annexed the land.

[7] Advanced Placement classes are offered at Neenah, and about 30 percent of students take an AP exam.

[10] The team made three consecutive returns to the Division I state tournament in the 2020's, winning outright in 2022 against Brookfield Central, and losing in the first round to Arrowhead in 2023 and 2024.

Additionally Neenah High School has one advanced orchestra group known as Touch of Class, a group which often performs around the Fox Valley and abroad[15] Neenah High was featured on an episode of the MTV television series If You Really Knew Me which aired on Tuesday, September 14, 2010.