The Holy Forty Martyrs of Sebastia Cathedral (Arabic: كاتدرائية الأربعين شهيدا) is a cathedral located in the Old City of Homs, Syria, dedicated to the Forty Martyrs of Sebaste.

It is the official see of the Greek Orthodox Archbishop of Homs and Dependencies.

A "beautiful church dedicated to the Forty Martyrs" standing in Homs was already mentioned by Joos van Ghistele in the 15th century.

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