The venue is the home ground of the EuroLeague and Italian Serie A professional basketball team AX Armani Exchange Milan.

The Forum received the 1994 European Prize for Architecture for sports venues awarded by the Italian National Olympic Committee and the Council of Europe.

It is also one of two facilities in Italy, along with Palazzo dello Sport in Rome, to be part of the European Arenas Association network.

The arena has hosted the 1994 Men's World Ice Hockey Championships, the 2003 IIHF Continental Cup Superfinal of ice hockey (together with Lugano's Pista La Resega), WWE Raw and WWE SmackDown in 2007, and the 2009 World Amateur Boxing Championships.

Since 2011, the Forum has also been home to La Grande Sfida, an annual tennis exhibition event played every Christmas.