The manga has been serialized in Kodansha's Weekly Shōnen Magazine since January 2021, with its chapters collected into twenty tankōbon volumes as of February 2025.

Set sixteen years after the destruction of the Demon King and Supreme Deity, at the hands of the Seven Deadly Sins, wrought the end of the Holy War, the series focuses on the young boy Percival, who discovers that he is destined to be part of a group of four knights prophesied to destroy the world.

[5] Following the conclusion of The Seven Deadly Sins on March 25, 2020, it was announced by the manga's author, Nakaba Suzuki, that his next work would serve as a sequel to the series.

[8] While planning the storyline for the manga, Suzuki originally desired to use the character of Tristan—who was introduced at the end of The Seven Deadly Sins as the son of Meliodas and Elizabeth Liones—to be the protagonist of Four Knights of the Apocalypse.

[9][10] However, Suzuki eventually changed his mind, not wanting to have a main character so closely related to the cast of his previous series.

In May 2022, it was announced that the manga would receive an anime television series adaptation, titled The Seven Deadly Sins: Four Knights of the Apocalypse.

[59] Produced and planned by TMS Entertainment,[a] and animated by Telecom Animation Film, it is directed by Maki Odaira, with scripts written by Shigeru Murakoshi, character designs handled by Youichi Takada, and music composed by Kohta Yamamoto, with the main theme composed alongside Hiroyuki Sawano.