Featuring a mix of comedies and drama series, the channel's programming targeted adults from 18 to 35 years old.

Non-Fox-produced shows rerun or receiving their UK premiere on the channel include The Walking Dead,[6] Falling Skies,[6] Babylon 5, Carnivàle, Highlander, JAG,[6] NCIS,[6] Sleeper Cell, E-Ring and Huff, Nip/Tuck, Generation Kill, True Blood,[6] Mob City and Dexter.

[13] On 5 January 2010, FX HD increased its broadcast hours to match its SD counterpart.

[1] New programmes added to the schedule included Louie, The Ricki Lake Show, Men at Work, Da Vinci's Demons and the second season of The Increasingly Poor Decisions of Todd Margaret, while many of the programmes that featured on FX continued to broadcast such as The Walking Dead, Dexter, True Blood, Falling Skies, Family Guy, and NCIS.

Fox also planned to commission up to 50 hours of original UK content by the end of the year, expecting to spend between £5m and £10m.

[18] On 17 May 2021, Disney announced that Fox would be closing at the end of June, with all of the channel's content moving to Star hub of Disney+.

[2] "On 30 June, the Fox channel in the UK will close," announced a spokesperson for the broadcaster.

We appreciate the support of our UK fans and can't wait to keep sharing the best stories with you.

[22] In addition to British and American programming, the channel has aired a number of international programmes.

These include Last Man Standing and The Nominees from Australia; Jo from France; Charlie Jade, a co-production between Canada and South Africa; and the Flemish series Matrioshki, which was shown with subtitles.

For several weeks from 5 December 2005, FX carried a strand of programming from the Fox-owned American channel Fuel TV.

In August 2015, Fox announced that a variety of Adult Swim programming would air on the channel including adult animated sci-fi comedy Rick and Morty, starting Thursday, 10 September of that year.

[23] On 10 September 2015, Adult Swim moved to Fox along with truTV, airing Rick and Morty and Mr. Pickles as its first day line up.