On 14 January 2021, Fox Odoi-Oywelowo was elected as a member of Uganda's Eleventh Parliament representing the West Budama North East constituency.

In 1999, he led a State House special audit team into the Uganda Revenue Authority (URA), to probe tax evasion.

A Locus Classicus of Fox Odoi-Oywelowo and James Akampumuza V Attorney General is taught in all law schools in Uganda.

While at State House, he was also appointed a member of the Expanded Committee of Inquiry into the causes of the clashes between the Uganda Peoples’ Defense Forces (UPDF) and the Rwanda Patriotic Front (RPF) in Kisangani.

[2] In 2010, Odoi-Oywelowo joined the Directorate of Civil Litigation in Uganda's Justice and Constitutional Affairs Ministry, serving as senior principal state attorney.

In 2011, Fox Odoi-Oywelowo was elected as a member of the Ninth Parliament of Uganda, representing the West Budama North constituency.

Fox Odoi-Oywelowo was on 14 January 2021, re-elected to the Parliament of Uganda to represent the West Budama North East constituency, winning a seat as a member of the ruling National Resistance Movement (NRM) party.