Fraenkel Gallery’s exhibitions have spanned photography's history while exploring the medium’s role in the evolution of art, highlighting links between early photographic pioneers and multi-disciplinary artists of today.

[5] The gallery maintains a robust publishing program, producing more than 77[6] books and a wide range of posters to date, including titles that accompany specific exhibitions and coincide with anniversaries.

In the gallery’s first decade, it brought new attention to under-recognized photographs by seldom-exhibited 19th-century artists including Watkins, Timothy O’Sullivan, Anna Atkins, and Eadweard Muybridge.

[10] In the 2010s, Fraenkel Gallery exhibited an increasingly wider swath of multi-disciplinary work, as well as video, sculpture, paintings, film posters, and record albums.

The program has presented exhibitions curated by artists from various disciplines, including Carrie Mae Weems’s selection of photographs by Diane Arbus, Sir Elton John’s take on Peter Hujar, and film director Joel Coen’s view of Lee Friedlander.