His wife Anne Julie de Rohan was the one-time mistress of Louis XIV and mother of François's own eleven children.

His older sister was Marie de Rohan, wife of the Duke of Chevreuse, Duke of Luynes and a key figure of the Fronde, the great civil war which threatened the power of the monarchy.

The church of Soubise, Charente-Maritime the Église Saint-Pierre, had been severely damaged during the European wars of religion.

Between 1700 and 1712, the church was rebuilt and restored to its original grand proportions at the cost of the prince.

Residing at the hôtel, François outlived his wife by three years, dying there 12 August 1712.