Flowing south, it passes Tuchitua, where the Nahanni Range Road branches off from the Yukon Highway 4 (Robert Campbell Highway).

The Yukon Highway 4 runs parallel to the river for a while before it crosses the river about 25 km (16 mi) from the mouth and continues to Watson Lake.

The Frances River has a length of about 140 km (87 mi).

At the level at the highway bridge, the mean discharge is 157 m3/s (5,500 cu ft/s).

This article related to a river in Yukon, Canada is a stub.