Francesco Appiani (January 29, 1704 – 1792) was an Italian painter of the late-Baroque period, active mainly in Rome and Perugia.
He was a pupil of Domenico Simonetti, and then later moved to Rome to study under Francesco Trevisani, Francesco Mancini, and Giovanni Paolo Pannini.
He also painted lunettes for a church of a Benedictine convent dedicated to fallen women.
In the chapel was an altarpiece by his contemporary Sebastiano Conca.
The vault was frescoed by Cesare Sermei and the high altar had a painting by Matteo Salvucci.