Francesco II Sforza (4 February 1495 – 2 November 1535) was Duke of Milan from 1521 until his death.

His father was imprisoned in Loches by Louis XII of France, and died in 1508, but when Charles V re-conquered Milan from the French in 1521, Francesco was appointed its duke,[1] the last of the family to hold that title.

[2] He returned to his state, depleted by twenty years of combat, promoting a cultural and economic recovery.

In 1526 he switched sides, joining the League of Cognac, together with Francis I of France, Pope Clement VII and the Republic of Florence, and was besieged in the Castello Sforzesco.

His half-brother Giovanni Paolo reclaimed briefly the Duchy of Milan after his death, but died in the same year under mysterious circumstances.