He was an ardent worker and prolific writer, 325 memoirs and communications appearing under his name in the Biblioteca Italiana and the Bibliothèque universelle de Genève.

In 1829 and again in 1830, Zantedeschi published papers on the production of electric currents in closed circuits by the approach and withdrawal of a magnet, thereby anticipating Michael Faraday's classical experiments of 1831.

[1] While carrying out researches on the solar spectrum, Zantedeschi was among the first to recognize the marked absorption by the atmosphere of red, yellow, and green light.

Zantedeschi's experiments and papers on the repulsion of flames by a strong magnetic field (discovered by Michele Alberto Bancalari of the Pious Schools in 1847) attracted general attention at the time.

His principal works are: Ricerche sul termo-elettricismo dinamico (1838) and Trattato del Magnetismo e della Elettricità (1843).