[1] He was born on 18 August 1940, in Koboko District to Misaeli Onale, an elementary school teacher.
He attended Busoga College Mwiri for his O-Level and A-Level studies, graduating in 1964.
Later he was awarded a Diploma in Legal Practice from the Law Development Centre in Kampala, Uganda's capital city.
[2] On Sunday 16 May 2004, he was involved in a fatal automobile accident at Nakasongola on the Kampala-Gulu Highway.
[3] Francis Ayume authored a book "Criminal Procedure And Law in Uganda".