There he assisted George W. Ritchey who built many of America's first large reflecting telescopes.
Among his designs was the 100-inch (2,500 mm) telescope at that observatory, and a 50-foot (15 m) interferometer that he used to measure star diameters.
Gene Shoemaker used Pease's high quality photographs of the Moon to make its first geologic map.
He would later be involved in the design of the 200-inch (5,100 mm) Hale Telescope at the Mount Palomar Observatory.
In 1928 he made the first discovery of a planetary nebula within a globular cluster, later called Pease 1.