He was educated at Amersham Hall School and then at London University graduating B.A.
With his brother-in-law, Victor Horsley (1857–1916), he performed research involving localization of brain function via electrical stimulation of the cortex, and also demonstrated that the mammalian brain was capable of producing electric current.
In 1899 he described the "inexcitable" or "refractory phase" that takes place between nerve impulses.
In 1891, with Horsley, he delivered the Croonian Lecture before the Royal Society of London, entitled "On The Mammalian Nervous System: Its Functions, And Their Localization Determined By An Electrical Method".
In June 1892 he was elected a Fellow of the Royal Society[3] His body was interred at Wolvercote Cemetery.