Francis James Harrison (August 20, 1912 – May 1, 2004) was an American prelate of the Roman Catholic Church.

[2] He attended the University of Notre Dame in Indiana, where he played varsity baseball, before entering St. Bernard's Seminary in Rochester in 1931.

[4] Harrison practiced a collegial manner of governing, and worked to include laity and especially women in the diocesan affairs.

[2] In 1980 he called for the United States to cease its aid to El Salvador following the murder of three nuns, declaring, "As Christians and as Americans, we cannot condone our resources and our tax dollars being used to help any foreign government repress its own people so brutally.

[2] Shortly before reaching the mandatory retirement age of 75, Harrison resigned as bishop on June 16, 1987.