Joseph Thomas O'Keefe (March 12, 1919 – September 2, 1997) was an American prelate of the Roman Catholic Church who served as Bishop of Syracuse from 1987 to 1995.

[2] During his priestly ministry, he served as a curate at St. Luke's Church and biology instructor and dean at Cardinal Hayes High School in The Bronx.

[1] He was Secretary for Education and associate superintendent of Catholic schools in the Archdiocese, chancellor and vicar general, and pastor of St. John the Evangelist Church Archived 2009-09-01 at the Wayback Machine in Manhattan.

[2] He received his episcopal consecration on the following September 8 from Cardinal Terence Cooke, with Archbishop John Joseph Maguire and Bishop Harold Robert Perry, S.V.D., serving as co-consecrators, at St. Patrick's Cathedral.

[2] O'Keefe died from heart failure at St. Joseph's Hospital Health Center, Syracuse, New York, aged 78.