[citation needed] On 26 April 1832 in Rolleston on Dove, he married Frances Mosley, daughter of the Rev.
She was the granddaughter of the late Sir John Parker Mosley, 1st Baronet, and cousin to Sir Oswald Mosley, 2nd Baronet.
Francis and Frances had seven children: Economic difficulties in the 1840s led to Etruria Works and Etruria Hall being put up for sale, though only the hall was sold, because he had no inclination to live there, as the location had become compromised.
He built a new house on a small estate at Barlaston, which, if less grand, was in a better situation.
Wedgwood retired from business in 1876 and died at Barlaston, Staffordshire in 1888.