Francisco Ramírez de Madrid (died 1501) was a Spanish artillery officer, counselor of the Catholic Monarchs and Secretary of King Ferdinand II of Aragon.
He obtained a position as a clerk in the court of Henry IV of Castile in Segovia, and then became mayor of Toledo.
After the conquest of Granada, he returned to Madrid, where he accumulated many properties.
[citation needed] His second wife, whom he married in December 1491, was Beatriz Galindo the writer, humanist and preceptor of Queen Isabella I of Castile.
He died in 1501 while combating a Mudéjar insurrection in the Sierra of Ronda.