Francisco de Lucena (c. 1578 – 28 April 1643) was a Portuguese nobleman and King John IV's first Secretary of State (Head of Government), and the first after the Restoration War and end of the Iberian Union.

[2] In 1614, during the Iberian Union, he succeeded his uncle Fernando de Matos, as King Philip II of Portugal's Secretary of the Crown Council.

He advised King John to keep all titles and privileges given during the Filipino rule, as to avoid rebellions and acts of treachery against him.

[2] When the Archbishop of Braga, the Duke of Coimbra and the Marquess of Vila Real were charged with treason against the new monarch, Francisco de Lucena spared his indulgence and condemned them all to death by beheading, even providing the cleaver that had cut off Rodrigo Calderón's head in his execution in Madrid.

Easily (and falsely) incriminated by the Jesuit and his successor in the post of Secretary of State (Pedro Vieira da Silva) of having surrendered the Santa Luzia Fort, in Elvas, to the Spaniards, he was finally sentenced to beheading (with the same cleaver used in the Archbishop of Braga, the Duke of Coimbra and the Marquess of Vila Real case) on 28 April 1643.