Dom Francisco de Melo (1597 – 18 December 1651) was a Portuguese nobleman who served as a Spanish general during the Thirty Years' War.

[1] In 1638, Francisco was appointed viceroy of Sicily,[2] and two years later he was ambassador in Vienna.

[3] Francisco was marquis of the Portuguese Tor de Laguna, count of Assumar, and from 1641 to 1644, interim governor of the Southern Netherlands.

[4] When Francisco arrived in the Southern Netherlands, he already had an impressive political career.

He scored a victory against Antoine III de Gramont at the Battle of Honnecourt in May 1642.