Francisco was the son of Rodrigo de Orozco y Rivera, 1st Marquis of Mortara, and Victoria Porcia, a lady of German origin.
His father served Spain on the war fronts of Flanders, Italy, Africa and Portugal, also taking part in the Battle of Lepanto (1571).
[1] Francisco followed in his father's footsteps and fought in Italy and Catalonia, where in 1640 he became captain general of the army in Perpignan.
Appointed governor of Rosselló (1640), he became isolated from Castile when the Reapers' War broke out in Catalonia.
When the French invaded Roussillon in 1641, he took refuge in the Château Royal de Collioure, but had to withdraw after a siege of 4 weeks.