The Francois Vertefeuille House is located in the Town of Prairie du Chien, Wisconsin, United States.

It was added to the National Register of Historic Places in 1993.

[1] It is one of the oldest buildings in Wisconsin, and is designated as the oldest building in the state still located on its original site.

[2] The house was built between 1810 and 1820 using the pièce-sur-pièce à coulisse technique common in French-Canadian buildings of the time.

[3] It was expanded during the 1820s after it was bought by Francois Vertefeuille, who had originally moved to Prairie du Chien from The Canadas in 1809.