Frank C. Partridge (May 7, 1861 – March 2, 1943) was an American attorney, diplomat, and business executive from Vermont.

A Republican, he served briefly in the United States Senate, appointed to fill the vacancy left by the death of Frank L. Greene.

Partridge held local offices in Proctor, including town clerk and school board member.

As a prominent business leader and former diplomat, Partridge developed "senior statesman" status that led to service on various boards and commissions, in the 1910s and 1920s, including the state public safety committee that managed Vermont's participation in World War I and the public corporation that aided in Vermont's recovery following the Great Flood of 1927.

In December 1930, Governor John E. Weeks appointed Partridge to the U.S. Senate to fill the vacancy created by the death of Frank Greene.

[10] A Republican, he held several positions in local, state and national government, including: Proctor Town Clerk (1887–1889); school board member (1888–1889); Private Secretary to Secretary of War Redfield Proctor (1889–1890); Solicitor of the Department of State (1890–1893); United States Ambassador to Venezuela (1893–1894); U.S. Consul in Tangier, Morocco (1897–1898); Vermont State Senator (1898–1900); Member of Vermont's World War I Committee of Public Safety (1917–1919); member of the American Society of International Law's executive council (1906–1923); chairman of the commission to propose amendments to the Constitution of Vermont (1909); delegate to the Fifth Pan-American Conference in Santiago, Chile (1923); member of the New England Council (1925–1927); and president of the Vermont Flood Credit Corporation (following the Flood of 1927).

[11] In December, 1930 Partridge was appointed by Governor John E. Weeks to fill the Senate vacancy caused by the death of Frank L.