Calabro was born in Sant'Alessio in Aspromonte near Reggio Calabria, Kingdom of Italy, to Antonio, a master bootmaker, and Maria Romeo.
In 1959, he was elected to Fairfield Councill, in which year he also became President of the Cabramatta Chamber of Commerce.
[1] In 1970, Calabro was appointed to the New South Wales Legislative Council as a Liberal member.
After leaving the Council, he continued to be active in the community; on 1 January 2001 he was awarded the Centenary Medal for services to migrant welfare, and on 9 June 2003 he was made a Member of the Order of Australia for service to the Parliament of New South Wales and the Fairfield community.
[1] In May 2013,Frank was added to the New South Wales Government Multicultural Honour Roll for his role in assisting new migrants settle in Australia.