De Vol was born in Moundsville in Marshall County in northern West Virginia, and was reared in Canton, Ohio.

"[1] From the 1940s, De Vol wrote arrangements for the studio recordings of many top singers, including Nat King Cole, Ella Fitzgerald, Sarah Vaughan, Tony Bennett, Dinah Shore, Doris Day, Vic Damone and Jaye P. Morgan.

His single most famous arrangement is probably the haunting string and piano accompaniment to Cole's "Nature Boy", which was a United States Number One in 1948.

That same year, he released a version of "The Teddy Bears' Picnic" (Capitol Records 15420), that he arranged and sang lead vocals on.

De Vol was musical director (and occasionally seen) on Edgar Bergen's CBS Television prime-time game show Do You Trust Your Wife?

"Frank De Vol's orchestra" was featured on the NBC Television prime-time musical variety series The Lux Show Starring Rosemary Clooney (1957-1958).

[4] The My Three Sons theme was musically complex, with a marimba playing a triplet obligato (the famous tune "Chopsticks") over the melody in 44 time, and was a hit single in 1961.

He also had a recurring role in I'm Dickens, He's Fenster as Myron Bannister, Dickens & Fenster's boss; and appeared on The Cara Williams Show, I Dream of Jeannie, Gidget, Bonanza, Petticoat Junction - (1967 episode: "That Was the Night That Was" & 1969 episode: "The Organ Fund" - as Reverend Barton), Mickey starring Mickey Rooney, The Brady Bunch, Get Smart (at least 2 appearances as Professor Carleton) and The Jeffersons.

He had also comic roles as Chief Eaglewood, the head of the Thundercloud Boys' Camp in 1961's The Parent Trap, and as the onscreen narrator in Jerry Lewis's 1967 comedy film The Big Mouth.

[5] De Vol was initiated as an honorary member of the Gamma Omega chapter of Phi Mu Alpha Sinfonia, the national fraternity for men in music, in 1962.