Enders was born in Milwaukee, the son of a saloon owner in the city's German quarter.
According to Hannah Heidi Levy's Famous Wisconsin Artists and Architects Enders worked in the shop of Henry Baumgaertner.
At age 19 Enders traveled to Munich, Germany where he studied from 1879 to 1884[1] at the Royal Academy of Fine Arts with Alois Gabl and Wilhelm von Lindenschmit, especially history painting, genre works and landscape painting.
The death of Frank Enders was published in the Eau Claire Leader newspaper on July 1, 1921.
The death notice is dated June 29 and stated that Ender "belonged to the original artists colony established in the '1990s'.