Frank Ernst Gregory (July 25, 1888 – November 5, 1955) was a professional baseball player.

He was a right-handed pitcher for one season (1912) with the Cincinnati Reds.

For his career, he compiled a 2–0 record, with a 4.60 earned run average, and four strikeouts in 15⅔ innings pitched.

He was born in Spring Valley (town), Wisconsin and died in Beloit, Wisconsin at the age of 67.

This biographical article relating to an American baseball pitcher born in the 1880s is a stub.